Punjab family ravaged by Alzheimer’s banks on gene test

NEW DELHI: A curious case from Punjab has rattled not just Kuldeep Kaur and her family but even the experts who have been striving for over a year to solve her case. Kaur, a 32-year-old mother of two, was living a healthy life till September 2011 when she suddenly developed memory loss. She stopped recognizing people, forgot meals and became urinary incontinent — a pattern observed in her family including her father, grandfather, great grandmother and several other blood relatives.

Kaur had been suffering from an extremely rare disease called familial Alzheimer's that runs into families. This was declared two days ago in a genetic test conducted by a research group based in France.

"This is the first time we have come across any such patient. Her 26-year-old brother had approached us two years ago for genetic testing, fearing that he might also suffer from the same fate as his family members. We did some testing but the mutation in gene could not be identified. Finally, a research group in France offered to do the genetic testing for free and the results came in," said Dr Sunita Bijarniya Mahay, metabolic physician and geneticist at the Center of Genetic Medicine, Ganga Ram Hospital.

Now they will do predicting testing on the brother and Kuldeep's blood relatives, Dr Sunita said, to rule out or confirm the possibility of mutation of the same gene in them. "Though there is no cure for familial Alzheimer's, the tests would help them beat the angst. We can also try to manage the positive cases using best post possible medical intervention," she added.

According to Harmohan Singh, Kuldeep's brother, most of their family members could not survive beyond 50 years. "We always thought it was a family curse and would lead to the extermination of our whole generation. But the finding of the gene responsible for the deaths has given us new hope," he said. Singh was eight when his father passed away due to the same disease.

"Kuldeep's condition is also worsening each day. She has developed urinary incontinent and has become very weak. Her children have been the worst sufferers of the tragedy and no one knows what future they have. We are poor and it is really difficult for us to even think of getting the tests done on each family member," he said.

According to Dr I C Verma, director of the center of genetic medicine at Ganga Ram Hospital, India has the largest number of patients having genetic disorders because of large number of births (27 million per year), consanguineous marriages (within relations), high frequency thalessemia and sickle cell disease.

"Prenatal genetic testing, which can help in timely identification of these risk factors, is available at most centers in India. We are now trying to acquire high-end services like Microarray Analysis that can analyse the minutest change in chromosome and next generation sequencing to multiple genes for possible mutation in one go.

"These new technologies will lead to the identification of the cause of intellectual disability, muscle weakness , brain disorders and many other genetic disorders. This will also lead to the development of newer therapies," he said.

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Pictures: Civil War Shipwreck Revealed by Sonar

Photograph by Jesse Cancelmo

A fishing net, likely only decades old, drapes over machinery that once connected the Hatteras' pistons to its paddle wheels, said Delgado.

From archived documents, the NOAA archaeologist learned that Blake, the ship's commander, surrendered as his ship was sinking. "It was listing to port, [or the left]," Delgado said. The Alabama took the wounded and the rest of the crew and put them in irons.

The officers were allowed to keep their swords and wander the deck as long as they promised not to lead an uprising against the Alabama's crew, he added.

From there, the Alabama dropped off their captives in Jamaica, leaving them to make their own way back to the U.S.

Delgado wants to dig even further into the crew of the Hatteras. He'd like see if members of the public recognize any of the names on his list of crew members and can give him background on the men.

"That's why I do archaeology," he said.

(Read about other Civil War battlefields in National Geographic magazine.)

Published January 11, 2013

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Poisoned Lottery Winner's Kin Were Suspicious

Urooj Khan had just brought home his $425,000 lottery check when he unexpectedly died the following day. Now, certain members of Khan's family are speaking publicly about the mystery -- and his nephew told ABC News they knew something was not right.

"He was a healthy guy, you know?" said the nephew, Minhaj Khan. "He worked so hard. He was always going about his business and, the thing is: After he won the lottery and the next day later he passes away -- it's awkward. It raises some eyebrows."

The medical examiner initially ruled Urooj Khan, 46, an immigrant from India who owned dry-cleaning businesses in Chicago, died July 20, 2012, of natural causes. But after a family member demanded more tests, authorities in November found a lethal amount of cyanide in his blood, turning the case into a homicide investigation.

"When we found out there was cyanide in his blood after the extensive toxicology reports, we had to believe that ... somebody had to kill him," Minhaj Khan said. "It had to happen, because where can you get cyanide?"

In Photos: Biggest Lotto Jackpot Winners

Authorities could be one step closer to learning what happened to Urooj Khan. A judge Friday approved an order to exhume his body at Rosehill Cemetery in Chicago as early as Thursday to perform further tests.

Lottery Winner Murdered: Widow Questioned By Police Watch Video

Moments after the court hearing, Urooj Khan's sister, Meraj Khan, remembered her brother as the kind of person who would've shared his jackpot with anyone. Speaking at the Cook County Courthouse, she hoped the exhumation would help the investigation.

"It's very hard because I wanted my brother to rest in peace, but then we have to have justice served," she said, according to ABC News station WLS in Chicago. "So if that's what it takes for him to bring justice and peace, then that's what needs to be done."

Khan reportedly did not have a will. With the investigation moving forward, his family is waging a legal fight against his widow, Shabana Ansari, 32, over more than $1 million, including Urooj Khan's lottery winnings, as well as his business and real estate holdings.

Khan's brother filed a petition Wednesday to a judge asking Citibank to release information about Khan's assets to "ultimately ensure" that [Khan's] minor daughter from a prior marriage "receives her proper share."

Ansari may have tried to cash the jackpot check after Khan's death, according to court documents, which also showed Urooj Khan's family is questioning if the couple was ever even legally married.

Ansari, Urooj Khan's second wife, who still works at the couple's dry cleaning business, has insisted they were married legally.

She has told reporters the night before her husband died, she cooked a traditional Indian meal for him and their family, including Khan's daughter and Ansari's father. Not feeling well, Khan retired early, Ansari told the Chicago Sun-Times, falling asleep in a chair, waking up in agony, then collapsing in the middle of the night. She said she called 911.

"It has been an incredibly hard time," she told ABC News earlier this week. "We went from being the happiest the day we got the check. It was the best sleep I've had. And then the next day, everything was gone.

"I am cooperating with the investigation," Ansari told ABC News. "I want the truth to come out."

Ansari has not been named a suspect, but her attorney, Steven Kozicki, said investigators did question her for more than four hours.

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Senate Democrats urge Obama to bypass Republicans on the debt ceiling

Democratic leaders in the Senate on Friday urged President Obama to consider bypassing Congress to prevent the nation from defaulting on its spending obligations if lawmakers cannot agree to raise the nation’s $16.4 trillion debt ceiling next month.

In a joint letter that served as a warning to congressional Republicans, Senate Majority Leader Harry M. Reid (D-Nev.) and his leadership team encouraged Obama to “take any lawful steps” to avoid default — “without Congressional approval, if necessary.”

The letter appeared to be an effort to push the White House to play hardball in its negotiations with Republicans as the federal government edges up against a legally imposed limit on borrowing.

Republicans have insisted that they will not increase the government’s borrowing authority without deep spending cuts, including to entitlement programs. On Friday they rejected the idea of unilateral action by the president.

“The Democrat leadership hiding under their desks and hoping the President will find a way around the law on the nation’s maxed-out credit card is not only the height of irresponsibility, but also a guarantee that our national debt crisis will only get worse,” said Senate Minority Leader Mitch McConnell (R-Ky.) in a statement.

Michael Steel, a spokesman for House Speaker John A. Boehner (R-Ohio), said that Americans “will not tolerate” hiking the debt ceiling without spending cuts.

Obama has said he considers raising the limit — which the nation will hit in February — an obligation of Congress because doing so allows the government to pay off debts it has already incurred.

Unlike in the summer of 2011, when Obama negotiated with Boehner in an effort to pair a debt-ceiling increase with a broad deficit reduction package of spending cuts and new tax revenue, the president has insisted he will no longer negotiate spending concessions in exchange for a higher ceiling.

That has left both sides without a clear strategy for how to proceed in what is likely to be a bitter and protracted fight.

In their letter, Reid, Sen. Richard J. Durbin (D-Ill.), Sen. Charles E. Schumer (D-N.Y.) and Sen. Patty Murray (D-Wash.) indicate that they will support Obama if he moves without Congress.

They wrote that the GOP position to block a debt-limit increase unless Democrats agree to cuts in Medicare and Social Security is “outrageous and absurd.”

They urge Obama to act unilaterally “in the event that Republicans make good on their threat by failing to act, or by moving unilaterally to pass a debt limit extension only as part of unbalanced or unreasonable legislation.”

One option some congressional Democrats have long advocated would involve Obama invoking the 14th Amendment to the Constitution to declare congressional action unnecessary for raising the limit.

The amendment holds that the validity of the country’s public debt “shall not be questioned.” Some constitutional experts believe that statement means that Congress cannot tie the government’s hands to borrow funds to meet obligations the government has already incurred.

The White House has indicated that Obama does not believe the Constitution gives him the right to ignore the congressionally imposed limit on borrowing.

Officials have been less definitive, however, about another route: allowing the Treasury Department to mint a trillion-dollar platinum coin to bolster the nation’s assets. The seemingly wacky idea has been gaining traction in recent days because of a law that allows the Treasury to mint coins of any value.

Asked recently about the coin, White House press secretary Jay Carney pointedly refused to rule it out as an option — though he repeatedly indicated that there “is no plan B” to congressional action.

In his statement, McConnell called the coin idea “ridiculous” and accused Democrats of considering “outright abdication of Congressional responsibility” in order to avoid cutting spending. The letter from Senate leaders came a week after a similar suggestion from House Minority Leader Nancy Pelosi (D-Calif.). She told reporters last week that if she were president, she would invoke the 14th Amendment to raise the debt ceiling “in a second.”

“I’ve made my view very clear on that subject,” she said. But, she added, “I’m not the president of the United States.”

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US mulls aid to French in Mali, including drones

WASHINGTON: The US military is weighing support for French forces in Mali including surveillance drones, a US official said Friday, as Washington backed moves to deny safe haven to extremists in the country.

US commanders were looking at providing intelligence and aerial refueling tankers among a range of options, such as logistical backup and boosting intelligence sharing, which would involve surveillance drones, the official, who spoke on condition of anonymity, told AFP.

Backed by French air power, Mali on Friday unleashed an offensive against Islamist rebels who have seized control of the north of the West African country and are now threatening to push south.

Senior US officials held talks with their counterparts in the French capital and other allies on drawing up an action plan, the official said.

President Francois Hollande confirmed in Paris that French forces were supporting an attack aimed at repelling the Al-Qaeda-linked radicals who have triggered international alarm with moves towards the capital Bamako.

The United States said Friday it shared France's goal of denying the extremists safe haven in Mali.

"We are monitoring the situation closely," National Security Council spokesman Tommy Vietor told AFP.

"We have noted that the government of Mali has asked for support, and we share the French goal of denying terrorists a safe haven in the region."

Hollande gave no indication of the scale of French involvement, but said it would last "for as long as is necessary."

The American military has a network of air bases in Italy, Spain and elsewhere in the region that could provide refueling tankers and other assistance to the French.

Former colonial power France has warned that the Islamist rebels were seeking to transform the vast nation into a "terrorist state."

State Department spokesman Victoria Nuland meanwhile said Washington was "consulting very closely" with the French government on the fighting.

"Obviously we remain deeply concerned by the recent events in Mali. We echo the international community's condemnation of these recent aggressive acts."

Earlier Friday, French Defense Minister Jean-Yves Le Drian briefed his US counterpart Leon Panetta about the situation.

-AFP/ac

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Stop show on Nirbhaya: Bombay HC

NAGPUR: The Bombay high court's Nagpur bench has stayed the telecast of Sony TV's 'Crime Patrol' episode on the Nirbhaya gang-rape case till further orders.

The telecast was slated for Friday and Saturday. Social organization Bharatiya Stree Sangh had moved the high court challenging the telecast. Its counsel Harshada Kurhekar contended that the telecast of this episode might affect the judicial outcome of the case. She pointed out that the case was sub judice. The BSS contented that the episode was commercialization of the tragedy that had shocked the nation. It said it would "increase the misery of the victim's family as well as hurt the feelings of women in general".

The division bench of justices AP Lavande and Arun Chaudhari issued the order and sent notices to Sony Entertainment Pvt Ltd, Information and Broadcasting Ministry and Indian Broadcasting Foundation. The show was expected to reconstruct the December 16 brutal gang-rape and torture of a 23-year-old physiotherapist trainee by six men in south Delhi. She died in a Singapore hospital on December 29 because of grievous injuries. tnn

A social organization said that the episode was an attempt to commercialize the tragedy that had shocked the nation.

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Pictures: Civil War Shipwreck Revealed by Sonar

Photograph by Jesse Cancelmo

A fishing net, likely only decades old, drapes over machinery that once connected the Hatteras' pistons to its paddle wheels, said Delgado.

From archived documents, the NOAA archaeologist learned that Blake, the ship's commander, surrendered as his ship was sinking. "It was listing to port, [or the left]," Delgado said. The Alabama took the wounded and the rest of the crew and put them in irons.

The officers were allowed to keep their swords and wander the deck as long as they promised not to lead an uprising against the Alabama's crew, he added.

From there, the Alabama dropped off their captives in Jamaica, leaving them to make their own way back to the U.S.

Delgado wants to dig even further into the crew of the Hatteras. He'd like see if members of the public recognize any of the names on his list of crew members and can give him background on the men.

"That's why I do archaeology," he said.

(Read about other Civil War battlefields in National Geographic magazine.)

Published January 11, 2013

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Obama Promises Faster Transition in Afghanistan

President Obama and Afghan President Hamid Karzai said today that most U.S. combat operations in Afghanistan would end this spring, signaling a quickening troop drawdown that will bring the decade-long war to a close at the end of 2014.

"Our troops will continue to fight alongside Afghans when needed, but let me say it as plainly as I can: Starting this spring, our troops will have a different mission -- training, advising, assisting Afghan forces," Obama announced at an East Room news conference in Washington.

"It will be a historic moment and another step toward full Afghan sovereignty, something I know that President Karzai cares deeply about, as do the Afghan people," he said.

Administration officials said Afghan forces were "exceeding initial expectations" in their capabilities. Afghan security forces are expected to lead 90 percent of security operations across the country in February.

"By the end of next year -- 2014 -- the transition will be complete," Obama said. "Afghans will have full responsibility for their security, and this war will come to a responsible end."

The rosy assessments belied the serious political, economic and security challenges that remain.

Left unanswered by Obama and Karzai: How many U.S. troops might stay after 2014; what their mission would be and whether they could be effective; and whether the forces would have immunity from prosecution in Afghan courts.

Charles Dharapak/AP Photo

President Hamid Karzai Addresses Afghan Sovereignty at White House Watch Video

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Afghanistan Troop Surge Ends at Tumultuous Point Watch Video

Obama said he was still reviewing recommendations from the Pentagon and will make an announcement in the coming weeks after penning an anticipated bilateral security agreement with Afghanistan. Karzai said the exact number would be up to the United States to decide.

Both leaders confirmed in a statement that the United States "does not seek permanent bases in Afghanistan."

They also agreed today to turn over battlefield combatants held by the U.S. military in Afghanistan to Afghan government control, which has been long-sought by Karzai.

Roughly 66,000 U.S. troops are serving in Afghanistan. The military has proposed keeping several thousand troops in the country after 2014 as advisers, trainers and logistical support for Afghan forces; the White House has said it remains open to pulling out all troops entirely.

Obama's visit with Karzai was the first face-to-face encounter since the November election and since last year's dramatic increase in so-called green-on-blue attacks, when U.S. and NATO soldiers have been killed by the Afghans they are training or working alongside.

There were 45 insider attacks in 2012 that resulted in 62 deaths among coalition forces, including 35 Americans. There has been one attack already in the first 11 days of 2013.

The White House summit included a private Oval Office meeting between Obama, Karzai and Vice President Joe Biden. The trio also attended a private lunch in the Old Family Dining Room.

Karzai Thursday attended meetings with Defense Secretary Leon Panetta and top military brass at the Pentagon, where he was afforded all the pomp and circumstance accorded a head of state: a 21-gun salute, and marching bands and honor guards from the Army, Navy, Air Force, Marines and Coast Guard.

Karzai's relationship with the United States has at times been a rocky one as he has sometimes made critical statements about the allied troop presence in his country. U.S. officials believe he has made those comments out of political expediency to improve his standing with Afghans and show his independence.

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Bibles used by King, Lincoln to be part of Obama’s second inauguration

Martin Luther King Jr. carried a black leather King James Bible on his journeys as a young pastor starting out in Montgomery, Ala. He turned to this “traveling Bible” for inspiration, his family says, as he fought for freedom and equality.

President Obama will put his hand over King’s well-worn Bible at his public swearing-in at the U.S. Capitol on Jan. 21, the holiday celebrating the birthday of the slain civil rights leader. King’s Bible will be stacked with the burgundy velvet and gilded Bible used by President Abraham Lincoln at his first inauguration.

Obama chose the Lincoln Bible for his inauguration in 2009, making him the first president to do so since it was initially used in 1861. President Harry S. Truman also used two Bibles, as did Dwight D. Eisenhower and Richard M. Nixon.

The announcement about the Bibles, to be made publicly Thursday, is part of the slow unspooling of inaugural details that fascinates lovers of ceremonial Americana.

Presidential inaugurations have become more filled with rites, and such decisions are especially weighty now at a time when the White House is aware that Americans are struggling to come together.

King’s family said in a statement that he would be “deeply moved” to see Obama use the traveling Bible on Martin Luther King Jr. Day, “and we hope it can be a source of strength for the President as he begins his second term.”

“With the Inauguration less than two weeks away, we join Americans across the country in embracing this opportunity to celebrate how far we have come, honor the legacy of Martin Luther King Jr. through service, and rededicate ourselves to the work ahead,” the statement added.

According to the Presidential Inaugural Committee, which organizes the swearing-in ceremony, King traveled with various books, including this Bible. “It was used for inspiration and preparing sermons and speeches, including during Dr. King’s time as pastor of Dexter Avenue Baptist Church” in Montgomery, the committee said in a statement.

Obama and Vice President Biden will be sworn in privately on Sunday, Jan. 20 — the date required by the Constitution. For that first ceremony, Obama will use the family Bible of his wife’s family. According to the inaugural committee, that Bible “was a gift from the First Lady’s father, Fraser Robinson III, to his mother, LaVaughn Delores Robinson, on Mother’s Day in 1958. Mrs. Robinson was the first African-American woman manager of a Moody Bible Institute’s bookstore.” That Bible was the only one Michelle Obama’s grandmother used after that, a committee statement said.

For both the private and then the Monday public ceremonies, Biden will be sworn in with a Bible that has been in his family since 1893: a five-inch-thick volume with a Celtic cross on the cover. He also used it for his swearings-in as a U.S. senator and in 2009 as vice president.

Some aspects of the inaugural ceremony have changed slightly over the decades. Having official prayers offered dates only to the 1930s, historians say. But presidents have used Bibles to be sworn in since George Washington, even though the Constitution does not require it. The Constitution also does not require the phrase “So help me God” at the end, but that has become standard, said Donald Ritchie, the historian of the U.S. Senate.

He also noted that the image of the president’s spouse holding the Bible dates only to Lady Bird Johnson doing so in 1965.

Chief justices of the Supreme Court now traditionally deliver the oath, but Ritchie said any federal official can do so.

Several non-Christian members of Congress have recently used other scriptures, including Rep. Keith Ellison, the first Muslim elected to Congress, in 2007. The Minnesota Democrat used a Koran owned by Thomas Jefferson.

Obama veered from tradition in one key aspect of the ceremony: He invited Myrlie Evers-Williams, widow of slain civil rights figure Medgar Evers, to deliver the invocation prayer. It will be the first time a woman, and a layperson rather than clergy, has done so.

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Captain blames faulty brakes, motor for NY ferry accident

NEW YORK: The captain of a packed ferry that crashed into a New York City pier injuring 74 people blamed malfunctioning brakes and a faulty motor for the accident, US investigators said Thursday.

"As the boat was coming in, the captain found that the reverse thrust was not operating as anticipated," said Robert Sumwalt of the National Transportation Safety Board, which is investigating the accident.

The captain said there was also a problem with the motor on the vessel, telling investigators that at some point "both diesel engines shut off," while he steered it toward the pier, Sumwalt told reporters.

There were 326 passengers and five crew on board the ferry at the time of Wednesday's mishap.

The accident took place during the morning rush hour at Pier 11 in lower Manhattan's East River, not far from Wall Street. The ferry was arriving from New Jersey.

Sumwalt said the captain, who is 36 years old, has 12 years of experience as a ferryboat captain and tested negative for alchohol use, as did the entire crew. Results of drug testing have yet to be completed, he said.

Some witnesses reported that the ferry, the Seastreak Wall Street, was going too quickly as it approached the pier.

Weather conditions were good at the time of the accident, with hardly any wind and good visibility.

Dozens of ferries bring thousands of commuters from New Jersey or Brooklyn to Manhattan every day, but accidents are rare.

The most serious mishap, in October 2003, killed 11 people and injured 70 others when a Staten Island ferry slammed into a pier at full speed.

- AFP/ck

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